A combination of ketoprofen and interferon given for 6 months to IFN non-responders showed no biochemical or virological benefit (Can. J. Gastroenterol. 1997; 11: 294–7.), however in a recent clinical trial, ketoprofen plus Roferon was superior to Roferon alone. The results showed 32.5% vs. 10% response rates in naive patients (Journal of Viral Hepatitis 10(4): 306-309. July 2003).