Российское сообщество больных Гепатитом С

3.5.5 Geron Telomerase Activation

Usually the liver regenerates easily, but that doesn’t happen in most patients with chronic liver disease. Many studies have shown that shortened telomere (the end of a chromosome) lengths are observed in the livers of these patients. Studies in mice, in which the RNA component of the telomerase gene has been removed, show that these animals have increased sensitivity to liver damage. The Geron Corporation plans to use a gene-based therapy to deliver the telomerase gene into the liver to help it regenerate. An article in the February 18, 2000 issue of Science showed that telomerase gene therapy prevents the onset of cirrhosis in mice. This approach is currently under development for preclinical studies ( www.geron.com).



Яндекс цитирования

Сайт управляется системой uCoz