Российское сообщество больных Гепатитом С

3.1.4c Induction dosing

Induction dosing involves giving high doses of interferon once a day. In this trial, all patients with a sustained virologic response had an initial decline in HCV RNA levels of more than 3 logs within the first 4 weeks of treatment (Medscape Gastroenterology, 3[3] 2001).

At the AASLD Annual Meeting in Dallas, Texas, in October 2000, it was shown that a high daily dose of IFN alpha has no significant effect on the long-term results if the treatment schedule is changed to a 3-times-weekly regimen later on during therapy.

Induction doses are now being tested with the pegylated interferons,and ribavirin.



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