Российское сообщество больных Гепатитом С


Because there is no effective neutralizing antibody or vaccine for preventing hepatitis C virus (HCV) transmission, HCV can be transmitted to health care workers through accidental needlesticks. In a study reported in the journal Clinical Infectious Diseases, after the clinical onset of acute hepatitis, two health care workers who had sustained accidental needlesticks were treated with interferon (total dose, similar to 300 megaunits). Neither individual developed chronic hepatitis. This finding raises the possibility that treatment with low-dose interferon following an accidental needlestick may be beneficial, even when it is started after the clinical onset of hepatitis. - “Early Therapy with Interferon for Acute Hepatitis C Acquired Through a Needlestick.” Clinical Infectious Diseases, May 1997;24(5):992-994.

A more recent study showed 100% 2-year sustained virologic response with alfa interferon monotherapy for acute hepatitis C. In a small study with seven patients, high-dose treatment for one year (5 mil daily for was 12 weeks, followed by 3 MIU 3-times weekly for 40 weeks. This represents a total alfa interferon dose of 780 MIU. The results were that all seven of the seven treated patients (100%) with acute HCV infection had a sustained virologic response two years after completing therapy. By contrast, only two of ten (20%) of those with chronic hepatitis C in the comparative arm achieved a sustained virologic response. The difference was statistically significant (Digestive Disease Week 2000).



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